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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242388
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
4±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242388
Synonyms:
US10047093, 8-68 | US10392392, Example 8-68 | US10875864, EX. 8-68 | US9416132, 8-68
Type:
Small organic molecule
Emp. Form.:
C18H20ClN5
Mol. Mass.:
341.838
SMILES:
N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:4.7,wD:1.0,(-7.29,3.62,;-5.95,2.85,;-5.95,1.31,;-4.62,.54,;-3.29,1.31,;-3.29,2.85,;-4.62,3.62,;-1.95,.54,;-.62,1.31,;-.62,2.85,;.72,3.62,;2.05,2.85,;3.51,3.33,;4.42,2.08,;3.51,.84,;3.91,-.65,;2.82,-1.74,;3.22,-3.23,;4.71,-3.62,;5.8,-2.54,;7.29,-2.93,;5.4,-1.05,;2.05,1.31,;.72,.54,)|
Structure:
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