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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242393
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
56±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242393
Synonyms:
US10047093, 8-75 | US10392392, Example 8-75 | US10875864, EX. 8-75 | US9416132, 8-75
Type:
Small organic molecule
Emp. Form.:
C21H25FN4O
Mol. Mass.:
368.4478
SMILES:
CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(F)c3)n2n1 |r,wU:4.3,wD:7.10,(-7.95,2.08,;-6.62,2.85,;-6.62,4.39,;-7.95,3.62,;-5.29,2.08,;-3.95,2.85,;-2.62,2.08,;-2.62,.54,;-3.95,-.23,;-5.29,.54,;-1.28,-.23,;.05,.54,;.05,2.08,;1.38,2.85,;2.72,2.08,;4.18,2.56,;5.09,1.31,;4.18,.07,;4.58,-1.42,;3.49,-2.51,;3.89,-4,;5.38,-4.39,;6.47,-3.31,;7.95,-3.7,;6.07,-1.82,;2.72,.54,;1.38,-.23,)|
Structure:
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