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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242403
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
14±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242403
Synonyms:
US10392392, Example 8-86 | US10875864, EX. 8-86 | US9416132, 8-86
Type:
Small organic molecule
Emp. Form.:
C20H18F3N5O
Mol. Mass.:
401.385
SMILES:
FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(N[C@H]3CC[C@@H](CC3)C#N)nn12 |r,wU:22.26,wD:19.19,(7.52,-6.31,;7.12,-4.82,;8.6,-4.42,;5.63,-5.22,;6.72,-3.33,;5.23,-2.93,;4.09,-4.01,;2.6,-3.61,;2.2,-2.12,;3.29,-1.03,;4.78,-1.43,;2.89,.45,;3.8,1.7,;2.89,2.95,;1.43,2.47,;.09,3.24,;-1.24,2.47,;-1.24,.93,;-2.57,.16,;-3.91,.93,;-3.91,2.47,;-5.24,3.24,;-6.67,2.49,;-6.57,.93,;-5.24,.16,;-8.01,3.24,;-9.35,4,;.09,.16,;1.43,.93,)|
Structure:
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