Reaction Details Report a problem with these data
Target
Carbonic anhydrase 13
Ligand
BDBM246553
Substrate
n/a
Meas. Tech.
Thermal Shift Assay (TSA)
pH
7±n/a
Kd
66.7±n/a nM
Comments
extracted
Citation
 Zubriene, A; Capkauskaite, E; Gylyte, J; Ki?onaite, M; Tumkevicius, S; Matulis, D Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII. J Enzyme Inhib Med Chem 29:124-31 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 13
Synonyms:
CA13 | CAH13_HUMAN | Carbonic anhydrase | Carbonic anhydrase 13 (CA XIII) | Carbonic anhydrase XIII (CA XIII)
Type:
Enzyme
Mol. Mass.:
29445.78
Organism:
Homo sapiens (Human)
Description:
Q8N1Q1
Residue:
262
Sequence:
MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH
  
Inhibitor
Name:
BDBM246553
Synonyms:
2-Chloro-4-{[2-(hydroxymethyl)-1H-benzimidazol-1-yl]acetyl}benzenesulfonamide (2c)
Type:
Small organic molecule
Emp. Form.:
C16H14ClN3O4S
Mol. Mass.:
379.818
SMILES:
NS(=O)(=O)c1ccc(cc1Cl)C(=O)Cn1c(CO)nc2ccccc12
Structure:
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