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Target
Bromodomain-containing protein 4 [75-147]
Ligand
BDBM249288
Substrate
n/a
Meas. Tech.
Amplified Luminescent Proximity Homogeneous Assay (ALPHA)
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
25.1±n/a nM
Comments
extracted
Citation
 Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent  US9458145 Publication Date 10/4/2016 
Target
Name:
Bromodomain-containing protein 4 [75-147]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1
Type:
n/a
Mol. Mass.:
8856.55
Organism:
Homo sapiens (Human)
Description:
BD1 (75-147 aa) of O60885
Residue:
73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
  
Inhibitor
Name:
BDBM249288
Synonyms:
US10017501, Compound 1020-78 | US9458145, 1020-78
Type:
Small organic molecule
Emp. Form.:
C20H19F2N5O
Mol. Mass.:
383.3946
SMILES:
Cc1n[nH]c(C)c1-c1cc(cc2nc([nH]c12)C1CC1(F)F)-c1c(C)noc1C |(1.15,-3.3,;2.49,-2.53,;3.95,-3,;4.86,-1.76,;3.95,-.51,;4.72,.82,;2.49,-.99,;1.15,-.22,;1.15,1.32,;-.18,2.09,;-1.52,1.32,;-1.52,-.22,;-2.66,-1.25,;-2.03,-2.66,;-.5,-2.49,;-.18,-.99,;-2.43,-4.14,;-2.03,-5.63,;-3.52,-5.23,;-4.86,-4.46,;-4.86,-6,;-.18,3.63,;-1.43,4.54,;-2.76,3.77,;-.95,6,;.59,6,;1.06,4.54,;2.4,3.77,)|
Structure:
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