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Target
Glutathione S-transferase P/Tyrosine-protein kinase SYK
Ligand
BDBM255553
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
1.286±n/a nM
Comments
extracted
Citation
 Arrington, KL; DuBois, B; Debenham, JS; Liu, P; Northrup, AB; Szewczyk, JW; Wang, L; Wang, M Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors US Patent  US9499534 Publication Date 11/22/2016 
Target
Name:
Glutathione S-transferase P/Tyrosine-protein kinase SYK
Synonyms:
GST-Tyrosine-protein kinase SYK
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Glutathione S-transferase P
Synonyms:
FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST)
Type:
Enzyme
Mol. Mass.:
23353.53
Organism:
Homo sapiens (Human)
Description:
P09211
Residue:
210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ
  
Component 2
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM255553
Synonyms:
US9499534, 1.6
Type:
Small organic molecule
Emp. Form.:
C22H21F3N4O4S
Mol. Mass.:
494.487
SMILES:
COc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@@]1(O)CC[C@@H](CC1)C(O)=O |r,wU:28.34,24.27,(4.13,-5.65,;2.8,-6.42,;1.46,-5.65,;.13,-6.42,;-1.2,-5.65,;-2.54,-6.42,;-3.87,-5.65,;-5.2,-6.42,;-6.54,-5.65,;-6.54,-4.11,;-5.2,-3.28,;-3.87,-4.11,;-5.2,-1.74,;-5.2,-.2,;-3.66,-1.74,;-6.74,-1.74,;-1.2,-4.11,;.13,-3.34,;1.46,-4.11,;.13,-1.8,;-1.12,-.89,;-.64,.57,;.9,.57,;1.38,-.89,;1.99,1.66,;2.76,.33,;3.48,1.26,;4.57,2.35,;4.17,3.84,;2.68,4.24,;1.59,3.15,;5.26,4.93,;6.74,4.53,;4.86,6.42,)|
Structure:
Search PDB for entries with ligand similarity: