Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 1 [400-80]/Glutathione S-transferase P
Ligand
BDBM255702
Substrate
n/a
Meas. Tech.
High ATP Kinase Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
13.2±n/a nM
Comments
extracted
Citation
 Lobell, M; Hübsch, W; Schirok, H; Héroult, M; Brohm, D; Collin, M; Grünewald, S; Lustig, K; Bömer, U; Voehringer, V; Lindner, N Substituted benzothienyl-pyrrolotriazines and uses thereof US Patent  US9475815 Publication Date 10/25/2016 
Target
Name:
Fibroblast growth factor receptor 1 [400-80]/Glutathione S-transferase P
Synonyms:
GST-Fibroblast growth factor receptor 1 (FGFR-1)
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Glutathione S-transferase P
Synonyms:
FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST)
Type:
Enzyme
Mol. Mass.:
23353.53
Organism:
Homo sapiens (Human)
Description:
P09211
Residue:
210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ
  
Component 2
Name:
Fibroblast growth factor receptor 1 [400-800]
Synonyms:
BFGFR | CEK | FGFBR | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor 1 (FGFR-1) | HBGFR
Type:
Protein
Mol. Mass.:
45097.70
Organism:
Homo sapiens (Human)
Description:
aa 400-800
Residue:
401
Sequence:
KSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEP
  
Inhibitor
Name:
BDBM255702
Synonyms:
US9475815, 87
Type:
Small organic molecule
Emp. Form.:
C25H32N6OS
Mol. Mass.:
464.626
SMILES:
COc1cc(C)cc2cc(sc12)-c1cc(CN[C@H]2CC[C@H](CC2)N(C)C)n2ncnc(N)c12 |r,wU:20.25,17.18,(3.78,3.41,;2.7,2.32,;1.21,2.72,;.89,4.23,;-.58,4.7,;-.97,6.19,;-1.72,3.67,;-1.4,2.17,;-2.31,.92,;-1.4,-.33,;.06,.15,;.06,1.69,;-1.8,-1.81,;-.89,-3.06,;-1.8,-4.3,;-1.4,-5.79,;.09,-6.19,;1.18,-5.1,;.78,-3.61,;1.87,-2.53,;3.35,-2.93,;3.75,-4.41,;2.66,-5.5,;4.44,-1.84,;5.93,-2.24,;4.05,-.35,;-3.26,-3.83,;-4.6,-4.6,;-5.93,-3.83,;-5.93,-2.29,;-4.6,-1.52,;-4.6,.02,;-3.26,-2.29,)|
Structure:
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