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Target
Orexin receptor type 2
Ligand
BDBM256982
Substrate
n/a
Meas. Tech.
Fluorescent Imaging Plate Reader (FLIPR) Assay
Temperature
310.15±n/a K
IC50
4500±n/a nM
Comments
extracted
Citation
 Fieldhouse, C; Glen, A; Robinson, JS; Fujimoto, T Cyclopentylbenzamide derivatives and their use for the treatment of psychotic and cognitive disorders US Patent  US9493432 Publication Date 11/15/2016 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM256982
Synonyms:
US9493432, 104
Type:
Small organic molecule
Emp. Form.:
C21H17F3N6OS
Mol. Mass.:
458.459
SMILES:
Fc1ccc2nc(N[C@H]3CC(F)(F)C[C@H]3NC(=O)c3ccccc3-n3nccn3)sc2c1 |r|
Structure:
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