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Target
Isoform 5-HT4(E) of 5-hydroxytryptamine receptor 4 (H5-HT4(g))
Ligand
BDBM50278564
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
1600±0 nM
IC50
4700±0 nM
Citation
 Lluel, P; Palea, S Incontinence treatment methods US Patent  US9511061 Publication Date 12/6/2016 
Target
Name:
Isoform 5-HT4(E) of 5-hydroxytryptamine receptor 4 (H5-HT4(g))
Synonyms:
5-hydroxytryptamine receptor 4 (5-HT4e) | 5-hydroxytryptamine receptor 4 (H5-HT4(g)) | 5HT4R_HUMAN | HTR4
Type:
Enzyme
Mol. Mass.:
42755.22
Organism:
Homo sapiens (Human)
Description:
Q13639-5
Residue:
378
Sequence:
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLSGCSPVSSFLLLFCNRPVPV
  
Inhibitor
Name:
BDBM50278564
Synonyms:
CHEMBL471036 | Litoxetine | US9511061, Compound A
Type:
Small organic molecule
Emp. Form.:
C16H19NO
Mol. Mass.:
241.3282
SMILES:
C(OC1CCNCC1)c1ccc2ccccc2c1
Structure:
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