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Target
Bromodomain-containing protein 4 [368-440]
Ligand
BDBM259897
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
39.1±n/a nM
Citation
 Durden, DL; Morales, GA; Garlich, JR Thienopyranones as kinase and epigenetic inhibitors US Patent  US9505780 Publication Date 11/29/2016 
Target
Name:
Bromodomain-containing protein 4 [368-440]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1
Type:
Protein
Mol. Mass.:
8564.63
Organism:
Homo sapiens (Human)
Description:
BD2 (368-440 aa) of O60885
Residue:
73
Sequence:
KHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVV
  
Inhibitor
Name:
BDBM259897
Synonyms:
US9505780, JQ-1
Type:
Small organic molecule
Emp. Form.:
C22H23ClN4O2S
Mol. Mass.:
442.962
SMILES:
Cc1nnc2[C@@H](N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1)C(=O)OC(C)(C)C |c:6|
Structure:
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