Reaction Details Report a problem with these data
Target
Hepatocyte growth factor receptor
Ligand
BDBM259961
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
293.15±n/a K
IC50
210.8±n/a nM
Comments
extracted
Citation
 Zhao, Z; Wang, H; Wu, C; Qi, Q [1,2,4] triazol [4,3-A] pyridine derivative, preparation method therefor or medical application thereof US Patent  US9512121 Publication Date 12/6/2016 
Target
Name:
Hepatocyte growth factor receptor
Synonyms:
Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase
Type:
Protein
Mol. Mass.:
155559.73
Organism:
Homo sapiens (Human)
Description:
P08581
Residue:
1390
Sequence:
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM259961
Synonyms:
US9512121, 45
Type:
Small organic molecule
Emp. Form.:
C25H21N7O2S
Mol. Mass.:
483.545
SMILES:
COc1c(cnc2ccc(Sc3nnc4ccc(cn34)-c3cnn(C)c3)cc12)-c1c(C)noc1C |(2.85,-1.32,;4.19,-.55,;4.19,.99,;5.52,1.76,;5.52,3.3,;4.19,4.07,;2.85,3.3,;1.52,4.07,;.19,3.3,;.19,1.76,;-1.15,.99,;-1.15,-.55,;.1,-1.46,;-.38,-2.92,;-1.92,-2.92,;-2.95,-4.07,;-4.46,-3.75,;-4.93,-2.28,;-3.9,-1.14,;-2.39,-1.46,;-6.44,-1.96,;-7.68,-2.87,;-8.93,-1.96,;-8.45,-.5,;-9.22,.84,;-6.91,-.5,;1.52,.99,;2.85,1.76,;6.85,.99,;6.85,-.55,;5.52,-1.32,;8.32,-1.03,;9.22,.22,;8.32,1.46,;9.09,2.8,)|
Structure:
Search PDB for entries with ligand similarity: