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Target
Serine/threonine-protein phosphatase 2A activator
Ligand
BDBM50054344
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1.09e+3± 4e+1 nM
Citation
 Zhang, Z; Zeng, L Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) US Patent  US9522881 Publication Date 12/20/2016 
Target
Name:
Serine/threonine-protein phosphatase 2A activator
Synonyms:
PP2A, subunit B', PR53 isoform | PTPA_MOUSE | Phosphotyrosyl phosphatase activator | Ppp2r4 | Ptpa | Serine/threonine-protein phosphatase 2A regulatory subunit 4 | Serine/threonine-protein phosphatase 2A regulatory subunit B'
Type:
Protein
Mol. Mass.:
36708.70
Organism:
Mouse
Description:
P58389
Residue:
323
Sequence:
MAEGERQPPPDSSEETPPTTQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFDYKVSEAIEKLVALLDTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDQEAENLVATVVPTHLAAAVPEVAVYLKEAVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQVAIVFKVFDRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPHLEPRHFVDEKAVSENHKDYMFLQCILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
  
Inhibitor
Name:
BDBM50054344
Synonyms:
CHEMBL3319356 | US9522881, 11a-1 L97M74 | US9844535, ID 11a-1 L97M74
Type:
Small organic molecule
Emp. Form.:
C28H20IN3O5S
Mol. Mass.:
637.445
SMILES:
Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1
Structure:
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