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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM459460
Substrate
n/a
Meas. Tech.
HPK1 Kinase Binding Assay
Ki
<100±n/a nM
Citation
 Sokolsky, A; Vechorkin, O; Wang, A; Ye, Q; Yao, W Indazole compounds and uses thereof US Patent  US10752635 Publication Date 8/25/2020 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM459460
Synonyms:
US10752635, Example 14, Peak 2 | US11492354, Example 14, Peak 2
Type:
Small organic molecule
Emp. Form.:
C27H21F2N5O2
Mol. Mass.:
485.4847
SMILES:
COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1cc(F)c2nn(C)cc2c1-c1ccccc1C |(-.62,-3.29,;-1.95,-4.06,;-3.29,-3.29,;-3.29,-1.75,;-4.62,-.98,;-5.96,-1.75,;-5.96,-3.29,;-7.29,-4.06,;-4.62,-4.06,;-4.62,-5.6,;-5.96,-6.37,;-5.96,-7.91,;-4.62,-8.68,;-3.29,-7.91,;-3.29,-6.37,;-1.95,-8.68,;-1.95,-10.22,;-.62,-7.91,;.71,-8.68,;.71,-10.22,;2.05,-10.99,;2.05,-12.53,;3.38,-10.22,;4.84,-10.69,;5.75,-9.45,;7.29,-9.45,;4.84,-8.2,;3.38,-8.68,;2.05,-7.91,;2.05,-6.37,;.71,-5.6,;.71,-4.06,;2.05,-3.29,;3.38,-4.06,;3.38,-5.6,;4.71,-6.37,)|
Structure:
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