Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM406471
Substrate
n/a
Meas. Tech.
Intracellular cAMP Accumulation Assay
EC50
5.5±n/a nM
Citation
 Johnson, JA; Kim, S 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists US Patent  US10336739 Publication Date 7/2/2019 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM406471
Synonyms:
6-butyl-5-(2,6- dimethoxyphenyl)- 3-[5-(2-methyl-1- phenylpropan-2- yl)-1,3,4-oxadiazol- 2-yl]pyridine-2,4- diol | US10336739, Example 64
Type:
Small organic molecule
Emp. Form.:
C29H33N3O5
Mol. Mass.:
503.5894
SMILES:
CCCCc1nc(O)c(-c2nnc(o2)C(C)(C)Cc2ccccc2)c(O)c1-c1c(OC)cccc1OC |(-7.59,-2.56,;-6.25,-3.33,;-4.92,-2.56,;-3.59,-3.33,;-2.25,-2.56,;-2.25,-1.02,;-.92,-.25,;-.92,1.29,;.42,-1.02,;1.75,-.25,;3.16,-.88,;4.19,.27,;3.42,1.6,;1.91,1.28,;3.81,3.09,;3.42,4.58,;2.33,3.49,;5.3,3.49,;5.7,4.98,;7.19,5.37,;7.59,6.86,;6.5,7.95,;5.01,7.55,;4.61,6.06,;.42,-2.56,;1.75,-3.33,;-.92,-3.33,;-.92,-4.87,;.42,-5.64,;1.75,-4.87,;3.08,-5.64,;.42,-7.18,;-.92,-7.95,;-2.25,-7.18,;-2.25,-5.64,;-3.59,-4.87,;-4.92,-5.64,)|
Structure:
Search PDB for entries with ligand similarity: