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Target
Serine/threonine-protein kinase PLK4 [1-391]
Ligand
BDBM50073587
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<100±n/a nM
Citation
 Sampson, PB; Liu, Y; Li, S; Forrest, BT; Pauls, HW; Edwards, LG; Feher, M; Patel, NK; Laufer, R Kinase inhibitors and method of treating cancer US Patent  US10358436 Publication Date 7/23/2019 
Target
Name:
Serine/threonine-protein kinase PLK4 [1-391]
Synonyms:
PLK4 | PLK4_HUMAN | SAK | STK18 | Serine/threonine-protein kinase PLK4
Type:
Protein
Mol. Mass.:
43940.49
Organism:
Homo sapiens (Human)
Description:
aa 1-391
Residue:
391
Sequence:
MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQA
  
Inhibitor
Name:
BDBM50073587
Synonyms:
CHEMBL3408947 | US10358436, Example A185 | US20230365537, Example CFI-400495 | US9907800, Example A185
Type:
Small organic molecule
Emp. Form.:
C33H34N4O3
Mol. Mass.:
534.6481
SMILES:
COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1 |r|
Structure:
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