Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM410237
Substrate
n/a
Meas. Tech.
Measurement of Antagonistic Activity Against Orexin Receptors
IC50
>10000±n/a nM
Citation
 Nagase, H; Yamamoto, N; Irukayama, Y; Saitoh, T; Yanagisawa, M; Nagumo, Y Morphinan derivative and medical usage thereof US Patent  US10377763 Publication Date 8/13/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM410237
Synonyms:
N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(phenylsulfonyl)-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methylcinnamide | US10377763, Example 38
Type:
Small organic molecule
Emp. Form.:
C31H34N2O5S
Mol. Mass.:
546.677
SMILES:
COc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)N(C)Cc1ccccc1)S(=O)(=O)c1ccccc1 |r|
Structure:
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