Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM410247
Substrate
n/a
Meas. Tech.
Measurement of Antagonistic Activity Against Orexin Receptors
IC50
>10000±n/a nM
Citation
 Nagase, H; Yamamoto, N; Irukayama, Y; Saitoh, T; Yanagisawa, M; Nagumo, Y Morphinan derivative and medical usage thereof US Patent  US10377763 Publication Date 8/13/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM410247
Synonyms:
US10377763, Example 42
Type:
Small organic molecule
Emp. Form.:
C32H35N3O6S
Mol. Mass.:
589.702
SMILES:
COc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)N(C)C(=O)NCc1ccccc1)S(=O)(=O)c1ccccc1 |r,TLB:18:19:6.5.15:8.10.9,20:19:6.5.15:8.10.9|
Structure:
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