Reaction Details Report a problem with these data
Target
Epoxide hydrolase
Ligand
BDBM50327846
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
18.0±n/a nM
Citation
Guedes, AG; Hammock, BD; Morisseau, C Treatment of inflammatory disorders in non-human mammals US Patent US10383835 Publication Date 8/20/2019
More Info.:
Target
Name:
Epoxide hydrolase
Synonyms:
EPHX1
Type:
Enzyme
Mol. Mass.:
52112.47
Organism:
Ovis aries (Sheep)
Description:
W5Q7Q6
Residue:
451
Sequence:
MWLEILLASVLGFVIYWFVSKDKEETLPLEDGWWGPGVRPTAGEDKSIRPFKVETSDEEINDLHQRIDRVRLTPPLEDSRFHYGFNSNYLKKIISYWRNEFDWRKQVEILNKYPHFKTKIEGLDIHFIHVKPPNLPSGQTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQKFYIQGGDWGALICTNMAQLVPSHIKGLHLNMALILRNFYTLTLPLGRCFGGLFGYTERDMELIYPFKKIFFSLLRESGYMHIQSTKPDTVGCALNDSPVGLAAYILEKFSTWTNSEFRDLEDGGLERKFSLDDLLTGIMLYWTTGTITSSQRFYKENLAQVNKHETLKVYVPTGFAAFPCELIHSPEKWVKTKYPKLISYSYMPRGGHFAAFEEPELLAQDIRKFVGLQERQ
Inhibitor
Name:
BDBM50327846
Synonyms:
1-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea | CHEMBL1257405 | US10383835, Compound 2214 | US9296693, 52
Type:
Small organic molecule
Emp. Form.:
C17H20F3N3O3
Mol. Mass.:
371.3542
SMILES:
FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)C(=O)C2CC2)cc1