Reaction Details Report a problem with these data
Target
Epoxide hydrolase 1
Ligand
BDBM50327846
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
190±n/a nM
Citation
 Guedes, AG; Hammock, BD; Morisseau, C Treatment of inflammatory disorders in non-human mammals US Patent  US10383835 Publication Date 8/20/2019 
Target
Name:
Epoxide hydrolase 1
Synonyms:
EPHX1
Type:
n/a
Mol. Mass.:
55532.32
Organism:
Felis catus (Cat) (Felis silvestris catus)
Description:
A0A2I2V3F9
Residue:
483
Sequence:
MLTSPSFSLGVTATMVPTVPSTCPRLLKGKGIMWLEILLASVLAFVVYWFVSRDKEETLPLEDGWWGPGARPTAPEDESIRPFKVETSDEEIKDLHRRIDGTRLTPPLEDSRFHYGFNSNYLKKILSYWRNEFDWRKQVEMLNRYPHFKTRIEGLDIHFVHVKPPQLPPGRTPKPLLMVHGWPGSFYEFYKIIPLLTDPANHGLSEEHVFEVICPSIPGYAFSEAASKKGLNSVATARIFYKLMLRLGFREFYIQGGDWGALICTHMAQMVPSHVKGLHLNMAFILNGRILTLFLVRHCPRLFGFTQRDMELMLPFKEKIFYKPLRESGYMHIQSTKPDTVGCALNDSPAGLAAYILEKFSTWTDSEFQELEDGGLERKFSLDDLLTNVMLYWTTGTITSSQRFYKENRGQLFKQDRVKVSVPTGLAAFPCELMHIPERWVKGKYPRLVSYSYMPRGGHFAALEEPELLARDIRKFVGLLELP
  
Inhibitor
Name:
BDBM50327846
Synonyms:
1-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea | CHEMBL1257405 | US10383835, Compound 2214 | US9296693, 52
Type:
Small organic molecule
Emp. Form.:
C17H20F3N3O3
Mol. Mass.:
371.3542
SMILES:
FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)C(=O)C2CC2)cc1
Structure:
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