Reaction Details Report a problem with these data
Target
G-protein coupled bile acid receptor 1
Ligand
BDBM411178
Substrate
n/a
Meas. Tech.
cAMP Assay
EC50
54.0±n/a nM
Citation
 Bissantz, C; Dehmlow, H; Erickson, SD; Karnachi, PS; Kim, K; Martin, RE; Mattei, P; Sander, UO; Pietranico-Cole, SL; Richter, H; Ullmer, C 3-amino-pyridines as GPBAR1 agonists US Patent  US10385022 Publication Date 8/20/2019 
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
35260.02
Organism:
Homo sapiens (Human)
Description:
CHO cells transiently transfected with hTGR5.
Residue:
330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
  
Inhibitor
Name:
BDBM411178
Synonyms:
N-(2-Amino-2-oxoethyl)-N-(4-(4,5-difluoro-2-methoxyphenyl)pyridin-3-yl)-2,6-bis(trifluoromethyl)isonicotinamide | US10385022, Example 174
Type:
Small organic molecule
Emp. Form.:
C22H14F8N4O3
Mol. Mass.:
534.3588
SMILES:
COc1cc(F)c(F)cc1-c1ccncc1N(CC(N)=O)C(=O)c1cc(nc(c1)C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: