Target
G-protein coupled bile acid receptor 1
Ligand
BDBM411200
Substrate
n/a
Meas. Tech.
cAMP Assay
EC50
23.0±n/a nM
Citation
 Bissantz, CDehmlow, HErickson, SDKarnachi, PSKim, KMartin, REMattei, PSander, UOPietranico-Cole, SLRichter, HUllmer, C 3-amino-pyridines as GPBAR1 agonists US Patent  US10385022 Publication Date 8/20/2019 
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
35260.02
Organism:
Homo sapiens (Human)
Description:
CHO cells transiently transfected with hTGR5.
Residue:
330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
  
Inhibitor
Name:
BDBM411200
Synonyms:
Methyl 2-(N-(4-(2-fluorophenyl)pyridin-3-yl)-2,6-bis(trifluoromethyl)isonicotinamido)acetate | US10385022, Example 196
Type:
Small organic molecule
Emp. Form.:
C22H14F7N3O3
Mol. Mass.:
501.3537
SMILES:
COC(=O)CN(C(=O)c1cc(nc(c1)C(F)(F)F)C(F)(F)F)c1cnccc1-c1ccccc1F
Structure:
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