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Target
Baculoviral IAP repeat-containing protein 2 [260-351]
Ligand
BDBM412167
Substrate
n/a
Meas. Tech.
TR-FRET Assays for cIAP BIR3
IC50
4.00±n/a nM
Citation
 Flohr, A; Galley, G; Norcross, R; Zorn, N Dimeric compounds US Patent  US10398702 Publication Date 9/3/2019 
Target
Name:
Baculoviral IAP repeat-containing protein 2 [260-351]
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | CIAP Bir3 | MIHB | RNF48
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10700.03
Organism:
Homo sapiens (Human)
Description:
Q13490[260-351]
Residue:
92
Sequence:
SISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGR
  
Inhibitor
Name:
BDBM412167
Synonyms:
(3S)-2-((S)-3,3-dimethyl- 2-((S)-2- (methylamino)propanamido) butanoyl)-7-(2-(6-(4- fluorobenzyl)-3-methyl-1- (2-((2R,5R)-5-methyl-2- (((R)-3 methylmorpholino)methyl) piperazin-1-yl)acetyl)indoline- 3-carboxamido)acetamido)- N-((R)-1,2,3,4- tetrahydronaphthalen-1- yl)-1,2,3,4- tetrahydroisoquinoline-3- carboxamide trihydrochloride | US10398702, Example 6
Type:
Small organic molecule
Emp. Form.:
C62H81FN10O7
Mol. Mass.:
1097.3677
SMILES:
CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)CNC(=O)C3(C)CN(C(=O)CN4C[C@@H](C)NC[C@@H]4CN4CCOC[C@H]4C)c4cc(Cc5ccc(F)cc5)ccc34)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C |r|
Structure:
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