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Target
Baculoviral IAP repeat-containing protein 2 [260-351]
Ligand
BDBM412174
Substrate
n/a
Meas. Tech.
TR-FRET Assays for cIAP BIR3
IC50
10.00±n/a nM
Citation
 Flohr, A; Galley, G; Norcross, R; Zorn, N Dimeric compounds US Patent  US10398702 Publication Date 9/3/2019 
Target
Name:
Baculoviral IAP repeat-containing protein 2 [260-351]
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | CIAP Bir3 | MIHB | RNF48
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10700.03
Organism:
Homo sapiens (Human)
Description:
Q13490[260-351]
Residue:
92
Sequence:
SISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGR
  
Inhibitor
Name:
BDBM412174
Synonyms:
US10398702, Example 13 | tert-Butyl (2R,5S)-4-[2-[3-[[2-[[(3S)-2-[(2S)-2-[[(2S)-2-[tert-butoxycarbonyl(methyl)amino]propanoyl]amino]-2-tetrahydropyran-4-yl-acetyl]-3-[(2,6-difluorophenyl)carbamoyl]-3,4-dihydro-1H-isoquinolin-7-yl]amino]-2-oxo-ethyl]carbamoyl]-6-[(4-fluorophenyl)methyl]-3-methyl-indolin-1-yl]-2-oxo-ethyl]-2-methyl-5-[[(3R)-3-methylmorpholin-4-yl]methyl]piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C59H73F3N10O8
Mol. Mass.:
1107.2683
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1Cc2cc(NC(=O)CNC(=O)C3(C)CN(C(=O)CN4C[C@@H](C)NC[C@@H]4CN4CCOC[C@H]4C)c4cc(Cc5ccc(F)cc5)ccc34)ccc2C[C@H]1C(=O)Nc1c(F)cccc1F |r|
Structure:
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