Reaction Details Report a problem with these data
Target
Interleukin-2
Ligand
BDBM412392
Substrate
n/a
Meas. Tech.
Human ELISA assay
IC50
9.00±n/a nM
Citation
 Chen, S; Bohnert, G; Jiang, J; Xia, Z Compounds for inflammation and immune-related uses US Patent  US10399967 Publication Date 9/3/2019 
Target
Name:
Interleukin-2
Synonyms:
IL-2 | IL2 | IL2_HUMAN | INN=Aldesleukin | Interleukin-2 | Interleukin-2 (IL-2) | T-cell growth factor | TCGF
Type:
Enzyme
Mol. Mass.:
17630.05
Organism:
Homo sapiens (Human)
Description:
P60568
Residue:
153
Sequence:
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
  
Inhibitor
Name:
BDBM412392
Synonyms:
5-fluoro-4-methyl-N-(5-(5-(1-methyl- 1H-pyrazol-4-yl)-2- (trifluoromethoxy)phenyl)pyrazin-2- yl)nicotinamide | US10399967, Compound 22
Type:
Small organic molecule
Emp. Form.:
C22H16F4N6O2
Mol. Mass.:
472.3951
SMILES:
Cc1c(F)cncc1C(=O)Nc1cnc(cn1)-c1cc(ccc1OC(F)(F)F)-c1cnn(C)c1
Structure:
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