Reaction Details Report a problem with these data
Target
TGF-beta receptor type-2
Ligand
BDBM412782
Substrate
n/a
Meas. Tech.
Biological Assays
IC50
26.0±n/a nM
Citation
 Harikrishnan, LS; Fink, BE; Borzilleri, RM; Tonukunuru, G; Sankara Warrier, J TGF beta receptor antagonists US Patent  US10399987 Publication Date 9/3/2019 
Target
Name:
TGF-beta receptor type-2
Synonyms:
TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
64559.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586859
Residue:
567
Sequence:
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
  
Inhibitor
Name:
BDBM412782
Synonyms:
N-(4-{[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}pyridin-2-yl)cyclopropanecarboxamide | US10399987, Example 47
Type:
Small organic molecule
Emp. Form.:
C21H18FN7O
Mol. Mass.:
403.4123
SMILES:
Cc1nc(ccc1F)-c1nc(Nc2ccnc(NC(=O)C3CC3)c2)c2cc[nH]c2n1
Structure:
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