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Target
Bromodomain-containing protein 4 [368-440]
Ligand
BDBM223494
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
29.5±n/a nM
Citation
 Bradner, JE; Qi, J Compositions and methods for treating neoplasia, inflammatory disease and other disorders US Patent  US10407441 Publication Date 9/10/2019 
Target
Name:
Bromodomain-containing protein 4 [368-440]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1
Type:
Protein
Mol. Mass.:
8564.63
Organism:
Homo sapiens (Human)
Description:
BD2 (368-440 aa) of O60885
Residue:
73
Sequence:
KHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVV
  
Inhibitor
Name:
BDBM223494
Synonyms:
US10407441, Compound JQ33 | US9320741, JQ33
Type:
Small organic molecule
Emp. Form.:
C25H29ClN6O2S
Mol. Mass.:
513.055
SMILES:
Cc1sc-2c(c1C)C(=NC(CC(=O)NCCN1CCOCC1)c1nnc(C)n-21)c1ccc(Cl)cc1 |c:8|
Structure:
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