Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM413869
Substrate
n/a
Meas. Tech.
Receptor Radioligand Assay
Ki
>500±n/a nM
Citation
 Virgili-Bernado, M; Alegret-Molina, C Substituted morpholine derivatives having activity against pain US Patent  US10421750 Publication Date 9/24/2019 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM413869
Synonyms:
7-(4-methoxybenzyl)-5-(1- phenethylpiperidin-4-yl)-4-oxa-7- azaspiro[2.5]octan-8-one | US10421750, Example 1
Type:
Small organic molecule
Emp. Form.:
C27H34N2O3
Mol. Mass.:
434.5705
SMILES:
COc1ccc(CN2CC(OC3(CC3)C2=O)C2CCN(CCc3ccccc3)CC2)cc1
Structure:
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