Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM413874
Substrate
n/a
Meas. Tech.
Receptor Radioligand Assay
Ki
>500±n/a nM
Citation
 Virgili-Bernado, M; Alegret-Molina, C Substituted morpholine derivatives having activity against pain US Patent  US10421750 Publication Date 9/24/2019 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM413874
Synonyms:
5-(1-ethylpiperidin-4-yl)-7-(4- methoxybenzyl)-4-oxa-7- azaspiro[2.5]octan-8-one | US10421750, Example 6
Type:
Small organic molecule
Emp. Form.:
C21H30N2O3
Mol. Mass.:
358.4745
SMILES:
CCN1CCC(CC1)C1CN(Cc2ccc(OC)cc2)C(=O)C2(CC2)O1
Structure:
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