Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM413898
Substrate
n/a
Meas. Tech.
Receptor Radioligand Assay
Ki
>500±n/a nM
Citation
 Virgili-Bernado, M; Alegret-Molina, C Substituted morpholine derivatives having activity against pain US Patent  US10421750 Publication Date 9/24/2019 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM413898
Synonyms:
4-((4-((2S,6R)-4-ethyl-6-methyl-5- oxomorpholin-2-yl)piperidin-1- yl)methyl)benzonitrile | US10421750, Example 34
Type:
Small organic molecule
Emp. Form.:
C20H27N3O2
Mol. Mass.:
341.4473
SMILES:
CCN1C[C@@H](O[C@H](C)C1=O)C1CCN(Cc2ccc(cc2)C#N)CC1 |r|
Structure:
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