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Target
Kappa-type opioid receptor
Ligand
BDBM414827
Substrate
n/a
Meas. Tech.
kappa-Opioid Receptor Binding Assay
Ki
2.16±0.45 nM
Citation
 Kassick, A; Tadesse, D; Tafesse, L 6,7-cyclicmorphinan derivatives and use thereof US Patent  US10435406 Publication Date 10/8/2019 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM414827
Synonyms:
(6R,6aS,11aR)-14-(cyclopropyl-methyl)- 2,6a-dihydroxy-5,6,6a,7,10a,11- hexahydro-6,11a-(epiminoethano)- naphtho[2,1-f]indol-9(10H)-one | US10435406, Compound 9
Type:
Small organic molecule
Emp. Form.:
C22H26N2O3
Mol. Mass.:
366.4534
SMILES:
Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC5NC(=O)C=C5C[C@@]34O)c2c1 |r,c:21|
Structure:
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