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Target
Kappa-type opioid receptor
Ligand
BDBM414829
Substrate
n/a
Meas. Tech.
kappa-Opioid Receptor Binding Assay
Ki
0.310±0.085 nM
Citation
 Kassick, A; Tadesse, D; Tafesse, L 6,7-cyclicmorphinan derivatives and use thereof US Patent  US10435406 Publication Date 10/8/2019 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM414829
Synonyms:
(6R,6aS,7aS,10aS,11aR)-14- (cyclopropylmethyl)-10-ethyl-2,6a- dihydroxy-5,6,6a,7,7a,8,10a,11- octahydro-6,11a-(epiminoethano)- naphtho[2,1-f]indol-9(10H)-one | US10435406, Compound 16
Type:
Small organic molecule
Emp. Form.:
C24H32N2O3
Mol. Mass.:
396.5225
SMILES:
CCN1[C@H]2C[C@]34CCN(CC5CC5)[C@H](Cc5ccc(O)cc35)[C@]4(O)C[C@H]2CC1=O |r|
Structure:
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