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Target
Hsp90 co-chaperone Cdc37
Ligand
BDBM279695
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
550±n/a nM
Citation
 Cai, X; Qian, C; Zhai, H Fused amino pyridine as HSP90 inhibitors US Patent  US10428068 Publication Date 10/1/2019 
Target
Name:
Hsp90 co-chaperone Cdc37
Synonyms:
CDC37 | CDC37A | CDC37_HUMAN | Hsp90 co-chaperone
Type:
Molecular Chaperone
Mol. Mass.:
44453.72
Organism:
Homo sapiens (Human)
Description:
Q16543
Residue:
378
Sequence:
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV
  
Inhibitor
Name:
BDBM279695
Synonyms:
US10035797, Compound 34 | US10035797, Compound 37 | US10428068, Compound 34 | US10844056, Compound 34 | US11560377, Compound 34 | US9630965, Compound 34
Type:
Small organic molecule
Emp. Form.:
C20H24IN5O2S
Mol. Mass.:
525.406
SMILES:
CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)nccc12
Structure:
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