Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Gamma-aminobutyric acid receptor subunit alpha-1
Ligand
BDBM419906
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
IC50
5000±n/a nM
Citation
Hasse, B; Koopmans, G 2-cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives US Patent US10472324 Publication Date 11/12/2019 More Info.:
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-1
Synonyms:
Benzodiazepine central | Benzodiazepine receptors | GABA A Benzodiazepine | GABA A Benzodiazepine Type I | GABA A Benzodiazepine Type II | GABA A Benzodiazepine Type IIL | GABA A Benzodiazepine Type IIM | GABA A Benzodiazepine omega1 | GABA A Benzodiazepine omega2 | GABA A Benzodiazepine omega5 | GABA A alpha1 | GABA A anti-Alpha1 | GABA receptor alpha-1 subunit | GABA, Chloride, TBOB | GABA-PICROTOXIN | GBRA1_RAT | Gabra-1 | Gabra1 | TBPS
Type:
Enzyme
Mol. Mass.:
51770.21
Organism:
Rattus norvegicus (Rat)
Description:
P62813
Residue:
455
Sequence:
MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
Inhibitor
Name:
BDBM419906
Synonyms:
US10472324, Example 9
Type:
Small organic molecule
Emp. Form.:
C14H11F3N2O3S2
Mol. Mass.:
376.374
SMILES:
OC(C1CC1)=C(C#N)C(=S)Nc1ccc(cc1)S(=O)(=O)C(F)(F)F |w:1.0|
Structure:
