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Target
Toll-like receptor 7
Ligand
BDBM420875
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
0.400±n/a nM
Citation
 Dyckman, AJ; Dodd, DS; Mussari, CP; Pasunoori, L; Kumar, SR [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds US Patent  US10478424 Publication Date 11/19/2019 
Target
Name:
Toll-like receptor 7
Synonyms:
ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)
Type:
Enzyme
Mol. Mass.:
120945.35
Organism:
Homo sapiens (Human)
Description:
Q9NYK1
Residue:
1049
Sequence:
MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFKETV
  
Inhibitor
Name:
BDBM420875
Synonyms:
US10478424, Example 567
Type:
Small organic molecule
Emp. Form.:
C28H32N6O
Mol. Mass.:
468.5933
SMILES:
COc1cc(cn2ncnc12)-c1[nH]c2ccc(cc2c1C(C)C)C1CCN(CC1)C1CC(C1)C#N |(10.48,.67,;8.94,.67,;8.17,-.67,;6.63,-.67,;5.86,-2,;6.63,-3.33,;8.17,-3.33,;9.2,-4.48,;10.61,-3.85,;10.45,-2.32,;8.94,-2,;4.32,-2,;3.41,-3.25,;1.95,-2.77,;.62,-3.54,;-.72,-2.77,;-.72,-1.23,;.62,-.46,;1.95,-1.23,;3.41,-.75,;4.18,.58,;3.41,1.91,;5.72,.58,;-2.05,-.46,;-3.39,-1.23,;-4.72,-.46,;-4.72,1.08,;-3.39,1.85,;-2.05,1.08,;-6.05,1.85,;-6.45,3.34,;-7.96,2.95,;-7.54,1.45,;-9.29,3.72,;-10.63,4.49,)|
Structure:
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