Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM386081
Substrate
n/a
Meas. Tech.
Measurement of Orexin Type 2 Receptor Agonist Activity
EC50
1200±n/a nM
Citation
 Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent  US10508083 Publication Date 12/17/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM386081
Synonyms:
N-((2R,3S)-2-(((cis-4-(2- (trifluoromethyl)phenyl)- cyclohexyl)oxy)methyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 23 | US10508083, Example 23 | US11292766, Example 23
Type:
Small organic molecule
Emp. Form.:
C20H29F3N2O3S
Mol. Mass.:
434.516
SMILES:
CS(=O)(=O)N[C@H]1CCCN[C@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1C(F)(F)F |r,wU:16.20,13.13,10.11,5.4,(6.67,-1.15,;5.33,-.38,;4.56,.95,;6.1,.95,;4,-1.15,;4,-2.69,;5.33,-3.47,;5.33,-5,;4,-5.78,;2.67,-5,;2.67,-3.47,;1.33,-2.69,;1.33,-1.15,;,-.38,;-1.33,-1.15,;-2.67,-.38,;-2.67,1.15,;-1.33,1.93,;,1.15,;-4,1.93,;-5.33,1.15,;-6.67,1.93,;-6.67,3.47,;-5.33,4.24,;-4,3.47,;-2.67,4.23,;-1.33,3.47,;-2.67,5.78,;-1.33,5,)|
Structure:
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