Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM386110
Substrate
n/a
Meas. Tech.
Measurement of Orexin Type 2 Receptor Agonist Activity
EC50
60.0±n/a nM
Citation
 Fujimoto, T; Rikimaru, K; Fukuda, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent  US10508083 Publication Date 12/17/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM386110
Synonyms:
2-(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)-3- ((methylsulfonyl)amino)piperidin-1-yl)- 2-oxoethyl acetate | US10287305, Example 47 | US10508083, Example 47 | US11292766, Example 47
Type:
Small organic molecule
Emp. Form.:
C20H36N2O6S
Mol. Mass.:
432.575
SMILES:
CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1C(=O)COC(C)=O)NS(C)(=O)=O |r,wU:3.2,6.9,11.11,12.25,(-6,3.47,;-4.67,4.23,;-4.67,5.78,;-3.33,3.47,;-3.33,1.93,;-2,1.15,;-.67,1.93,;-.67,3.47,;-2,4.23,;.67,1.15,;.67,-.38,;2,-1.15,;3.33,-.38,;4.67,-1.15,;4.67,-2.69,;3.33,-3.47,;2,-2.69,;.67,-3.47,;.67,-5,;-.67,-2.69,;-2,-3.47,;-2,-5,;-.67,-5.78,;-3.33,-5.78,;3.33,1.15,;4.67,1.93,;6,1.15,;3.9,3.26,;5.44,3.26,)|
Structure:
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