Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM422053
Substrate
n/a
Meas. Tech.
Cellular Necrosis Inhibition Activity
EC50
426±n/a nM
Citation
 Yuan, J; Zhou, Y; Qian, S; Ma, D Inhibitors of cellular necrosis and related methods US Patent  US10508102 Publication Date 12/17/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM422053
Synonyms:
5-((7-chloro-1H-indol-3-yl)methyl)- 3-(3,4-difluorobenzyl)imidazolidine- 2,4-dione | US10508102, Example II-3
Type:
Small organic molecule
Emp. Form.:
C19H14ClF2N3O2
Mol. Mass.:
389.783
SMILES:
Fc1ccc(CN2C(=O)NC(Cc3c[nH]c4c(Cl)cccc34)C2=O)cc1F
Structure:
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