Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM422055
Substrate
n/a
Meas. Tech.
Cellular Necrosis Inhibition Activity
EC50
892±n/a nM
Citation
 Yuan, J; Zhou, Y; Qian, S; Ma, D Inhibitors of cellular necrosis and related methods US Patent  US10508102 Publication Date 12/17/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM422055
Synonyms:
5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(2- fluorobenzyl)imidazolidine-2,4- dione | US10508102, Example II-5
Type:
Small organic molecule
Emp. Form.:
C19H14ClF2N3O2
Mol. Mass.:
389.783
SMILES:
Fc1ccccc1CN1C(=O)NC(Cc2c[nH]c3c(Cl)c(F)ccc23)C1=O
Structure:
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