Reaction Details Report a problem with these data
Target
WD repeat-containing protein 5
Ligand
BDBM423371
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy (FPA) Assay
Ki
3.35±n/a nM
Citation
 Fesik, SW; Stauffer, SR; Salovich, JM; Tansey, WP; Wang, F; Phan, J; Olejniczak, ET WDR5 inhibitors and modulators US Patent  US10501466 Publication Date 12/10/2019 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM423371
Synonyms:
US10501466, Example B6
Type:
Small organic molecule
Emp. Form.:
C23H21Cl2N3O
Mol. Mass.:
426.338
SMILES:
Clc1ccc(CC(=O)NC2CCc3ccc(cc23)-c2cn3CCCc3n2)cc1Cl
Structure:
Search PDB for entries with ligand similarity: