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Target
WD repeat-containing protein 5
Ligand
BDBM423385
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Anisotropy (FPA) Assay
Ki
95.6±n/a nM
Citation
 Fesik, SW; Stauffer, SR; Salovich, JM; Tansey, WP; Wang, F; Phan, J; Olejniczak, ET WDR5 inhibitors and modulators US Patent  US10501466 Publication Date 12/10/2019 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM423385
Synonyms:
US10501466, Example B20
Type:
Small organic molecule
Emp. Form.:
C21H19ClN4O
Mol. Mass.:
378.855
SMILES:
Clc1cc(ccn1)C(=O)N[C@@H]1CCc2ccc(cc12)-c1cn2CCCc2n1 |r|
Structure:
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