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Target
Interleukin-6
Ligand
BDBM423490
Substrate
n/a
Meas. Tech.
Interleukin 6 Induction Assay
EC50
5.91±n/a nM
Citation
 He, L; Gangwar, S; Poudel, YB; Sivaprakasam, P Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor US Patent  US10508115 Publication Date 12/17/2019 
Target
Name:
Interleukin-6
Synonyms:
B-cell stimulatory factor 2 | BSF-2 | CDF | CTL differentiation factor | Hybridoma growth factor | IFN-beta-2 | IFNB2 | IL-6 | IL6 | IL6_HUMAN | Interferon beta-2
Type:
n/a
Mol. Mass.:
23717.96
Organism:
Homo sapiens (Human)
Description:
P05231
Residue:
212
Sequence:
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
  
Inhibitor
Name:
BDBM423490
Synonyms:
US10508115, Compound Ib-09
Type:
Small organic molecule
Emp. Form.:
C27H31N7O3
Mol. Mass.:
501.5801
SMILES:
CCCCOc1nc(N)c2nc(O)n(Cc3ccc(Oc4ccc(CNC5C6CC5C6)cc4)nc3)c2n1 |THB:25:26:28:30,(-13.4,4.64,;-12.07,5.41,;-10.73,4.64,;-9.4,5.41,;-8.07,4.64,;-6.73,5.41,;-6.73,6.95,;-5.4,7.72,;-5.4,9.26,;-4.07,6.95,;-2.6,7.43,;-1.7,6.18,;-.16,6.18,;-2.6,4.94,;-2.6,3.4,;-1.27,2.63,;.07,3.4,;1.4,2.63,;1.4,1.09,;2.73,.32,;4.07,1.09,;5.4,.32,;6.73,1.09,;6.73,2.63,;8.07,3.4,;8.07,4.94,;6.73,5.71,;5.19,5.71,;5.49,8.15,;5.49,6.61,;4.15,5.84,;5.4,3.4,;4.07,2.63,;.07,.32,;-1.27,1.09,;-4.07,5.41,;-5.4,4.64,)|
Structure:
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