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Target
Calmodulin-domain protein kinase 1, putative
Ligand
BDBM50345727
Substrate
n/a
Meas. Tech.
luminescent kinase assay
IC50
59.0±n/a nM
Citation
 Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent  US10544104 Publication Date 1/28/2020 
Target
Name:
Calmodulin-domain protein kinase 1, putative
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
60946.72
Organism:
Cryptosporidium parvum (strain Iowa II)
Description:
A3FQ16
Residue:
538
Sequence:
MGNTAVGNTGTRLRAPVDAVVNTTNKKAPVSEKPSQPQIPNKTSDVKKGGTMGGERGSVTTGMFVQSGSGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQAEKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDSNSLIQNEGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDKDGSGKISTKELFKLFSQADSSIQMEELESIIEQVDNNKDGEVDFNEFVEMLQNFVRNE
  
Inhibitor
Name:
BDBM50345727
Synonyms:
1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL1785014 | US10544104, Compound 7e | US11247972, Compound 7e | US9765037, Compound 7e
Type:
Small organic molecule
Emp. Form.:
C17H21N5
Mol. Mass.:
295.3821
SMILES:
CC(C)c1cccc(c1)-c1nn(C(C)C)c2ncnc(N)c12
Structure:
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