Reaction Details Report a problem with these data
Target
Proto-oncogene Wnt-1
Ligand
BDBM293430
Substrate
n/a
Meas. Tech.
The screening assay for Wnt activity
EC50
62.0±n/a nM
Citation
 KC, SK; Mak, CC; Eastman, BW; Cao, J; Bollu, V; Mittapalli, GK; Chiruta, C Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent  US10544128 Publication Date 1/28/2020 
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM293430
Synonyms:
US10106527, Compound 16 | US10544128, Compound 16 | US11548872, Compound 16 | US20230286945, Compound 16 | US9951048, Compound 16
Type:
Small organic molecule
Emp. Form.:
C24H24N6O2
Mol. Mass.:
428.4864
SMILES:
Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(OC4CCNCC4)c3)cc2c1
Structure:
Search PDB for entries with ligand similarity: