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Target
Proto-oncogene Wnt-1
Ligand
BDBM293441
Substrate
n/a
Meas. Tech.
The screening assay for Wnt activity
EC50
4362±n/a nM
Citation
 KC, SK; Mak, CC; Eastman, BW; Cao, J; Bollu, V; Mittapalli, GK; Chiruta, C Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent  US10544128 Publication Date 1/28/2020 
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM293441
Synonyms:
US10106527, Compound 27 | US10544128, Compound 27 | US11548872, Compound 27 | US20230286945, Compound 27 | US9951048, Compound 27
Type:
Small organic molecule
Emp. Form.:
C26H27N7O2
Mol. Mass.:
469.5383
SMILES:
CNC(=O)c1ccc(cn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(c1)C1CCN(C)CC1
Structure:
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