Reaction Details Report a problem with these data
Target
A disintegrin and metalloproteinase with thrombospondin motifs 6
Ligand
BDBM429747
Substrate
n/a
Meas. Tech.
hADAMTS-6 Assay
IC50
12.5±n/a nM
Citation
Labéguère, FG; Heng, R; De Ceuninck, FA; Alvey, LJ; Amantini, D; Brebion, FL; Deprez, PM; Gosmini, RL; Jary, HM; Peixoto, C; Pop-Botez, IE; Varin, ML 5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis US Patent US10550100 Publication Date 2/4/2020
More Info.:
Target
Name:
A disintegrin and metalloproteinase with thrombospondin motifs 6
Synonyms:
ADAM-TS 6 | ADAM-TS6 | ADAMTS-6 | ADAMTS6 | ATS6_HUMAN
Type:
Protein
Mol. Mass.:
125276.26
Organism:
Human
Description:
Q9UKP5
Residue:
1117
Sequence:
MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH
Inhibitor
Name:
BDBM429747
Synonyms:
(R)-5-(3-(4- (3,4-dichloro-5- methoxyphenyl) piperidin-1- yl)-3- oxopropyl)-5- methylimidazolidine- 2,4-dione | US10550100, Compound 68
Type:
Small organic molecule
Emp. Form.:
C19H23Cl2N3O4
Mol. Mass.:
428.31
SMILES:
COc1cc(cc(Cl)c1Cl)C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r|