Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM431915
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
15.0±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes US Patent  US10550127 Publication Date 2/4/2020 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM431915
Synonyms:
((S)-6-{(R)-7-Fluoro-4-[4-(3-hydroxy-3-methyl-butoxy)-2,6-dimethyl-phenyl]-indan-1-ylamino}-2,3-dihydro-furo[3,2-c]pyridin-3-yl)-acetic Acid | US10550127, Example 1
Type:
Small organic molecule
Emp. Form.:
C31H35FN2O5
Mol. Mass.:
534.6184
SMILES:
Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1 |r,wU:31.34,wD:21.27,(-5.06,2.04,;-4.59,.57,;-5.62,-.57,;-5.14,-2.04,;-6.17,-3.18,;-7.68,-2.86,;-8.71,-4.01,;-10.22,-3.69,;-11.25,-4.83,;-10.69,-2.22,;-11.7,-3.29,;-3.64,-2.36,;-2.61,-1.21,;-1.1,-1.53,;-3.08,.25,;-2.05,1.4,;-2.53,2.86,;-1.5,4.01,;.01,3.69,;1.04,4.83,;.49,2.22,;1.89,1.59,;1.73,.06,;.22,-.26,;-.55,1.08,;3.23,2.36,;4.56,1.59,;5.89,2.36,;7.23,1.59,;8.69,2.07,;9.6,.82,;8.69,-.42,;9.17,-1.89,;10.67,-2.21,;11.7,-1.06,;11.15,-3.67,;7.23,.05,;5.89,-.72,;4.56,.05,)|
Structure:
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