Reaction Details Report a problem with these data
Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM432332
Substrate
n/a
Meas. Tech.
SMYD3 Biochemical Assay
IC50
5096±n/a nM
Citation
 Mitchell, LH; Bell, AS; Chesworth, R; Foley, MA; Kuntz, KW; Mills, JE; Munchhof, MJ Substituted piperidine compounds US Patent  US10577363 Publication Date 3/3/2020 
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
  
Inhibitor
Name:
BDBM432332
Synonyms:
(R)-5-cyclopropyl-N-(1-(3-hydroxy-2-(4- hydroxy-3- iodobenzyl)propanoyl)piperidin-4- yl)isoxazole-3-carboxamide | US10577363, Compound 31
Type:
Small organic molecule
Emp. Form.:
C22H26IN3O5
Mol. Mass.:
539.3634
SMILES:
OC[C@@H](Cc1ccc(O)c(I)c1)C(=O)N1CCC(CC1)NC(=O)c1cc(on1)C1CC1 |r|
Structure:
Search PDB for entries with ligand similarity: