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Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM433066
Substrate
n/a
Meas. Tech.
SMYD3 Biochemical Assay
IC50
0.880±n/a nM
Citation
 Mitchell, LH; Bell, AS; Chesworth, R; Foley, MA; Kuntz, KW; Mills, JE; Munchhof, MJ Substituted piperidine compounds US Patent  US10577363 Publication Date 3/3/2020 
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
  
Inhibitor
Name:
BDBM433066
Synonyms:
5-cyclopropyl-N-((1R,3r,5S)-8-(((1- methylpiperidin-4-yl)methyl)sulfonyl)-8- azabicyclo[3.2.1]octan-3-yl)isoxazole-3- carboxamide | US10577363, Compound 770
Type:
Small organic molecule
Emp. Form.:
C21H32N4O4S
Mol. Mass.:
436.568
SMILES:
CN1CCC(CS(=O)(=O)N2[C@H]3CC[C@@H]2C[C@@H](C3)NC(=O)c2cc(on2)C2CC2)CC1 |r,TLB:6:9:12.11:16.15.14|
Structure:
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