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Target
Neuroepithelial cell-transforming gene 1 protein
Ligand
BDBM433736
Substrate
n/a
Meas. Tech.
Functional Uptake Assay (hNET)
IC50
538±n/a nM
Citation
 Shao, L; Wang, F; Malcolm, SC; Hewitt, MC; Bush, LR; Ma, J; Varney, MA; Campbell, U; Engel, SR; Hardy, LW; Koch, P; Campell, JE Cycloalkylamines as monoamine reuptake inhibitors US Patent  US10562878 Publication Date 2/18/2020 
Target
Name:
Neuroepithelial cell-transforming gene 1 protein
Synonyms:
ARHG8_HUMAN | ARHGEF8 | NET1 | Proto-oncogene p65 Net1 | Rho guanine nucleotide exchange factor 8
Type:
PROTEIN
Mol. Mass.:
67762.41
Organism:
Homo sapiens
Description:
ChEMBL_118125
Residue:
596
Sequence:
MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPNWDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
  
Inhibitor
Name:
BDBM433736
Synonyms:
US10562878, Compound 147 E1 | US10562878, Compound 147 E2 | US10562878, Compound 148 E1 | US10562878, Compound 148 E2 | US10562878, Compound 163 E1 | US10562878, Compound 163 E2 | US10562878, Compound 164 E1 | US10562878, Compound 164 E2
Type:
Small organic molecule
Emp. Form.:
C19H25NO
Mol. Mass.:
283.4079
SMILES:
CN(C)CC1(CCCCC1O)c1ccc2ccccc2c1
Structure:
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