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Target
Neuroepithelial cell-transforming 1
Ligand
BDBM433736
Substrate
n/a
Meas. Tech.
Functional Uptake Assay (rNET)
IC50
500±n/a nM
Citation
 Shao, L; Wang, F; Malcolm, SC; Hewitt, MC; Bush, LR; Ma, J; Varney, MA; Campbell, U; Engel, SR; Hardy, LW; Koch, P; Campell, JE Cycloalkylamines as monoamine reuptake inhibitors US Patent  US10562878 Publication Date 2/18/2020 
Target
Name:
Neuroepithelial cell-transforming 1
Synonyms:
Net1 | Q498M6_RAT
Type:
Protein
Mol. Mass.:
61816.50
Organism:
Rat
Description:
Q498M6
Residue:
541
Sequence:
MVAHDEIGGLLPIKRTIRVLDVNNQPFREQEEPSNKRVRPLGRVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASTQKSFSRATVPTPTKRRSSALWSEMLDISMKESLTTREIKRQEAIYELSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDAYIPLHEDLLARIGEATKPDGTVEQIGHILVNWLPGLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHTPKDHLDVQLLEKAILIIQEVLSDINLKKGESECQYYIDKLEYLDEKQKDPRIEASKVLLCHGELKNKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFGNSDKAKNIFRVRFQDPSPGQSHTLQANDVFHKQQWFNCIRSAIAPFQRAASPLELQGLPDLHEECEENNPSAGNLRAQRRSCVLPGVMQVDHESVLECGSSVQTSEDTRNAKAHRPQHGLRRARDKAQLGGKKKETLV
  
Inhibitor
Name:
BDBM433736
Synonyms:
US10562878, Compound 147 E1 | US10562878, Compound 147 E2 | US10562878, Compound 148 E1 | US10562878, Compound 148 E2 | US10562878, Compound 163 E1 | US10562878, Compound 163 E2 | US10562878, Compound 164 E1 | US10562878, Compound 164 E2
Type:
Small organic molecule
Emp. Form.:
C19H25NO
Mol. Mass.:
283.4079
SMILES:
CN(C)CC1(CCCCC1O)c1ccc2ccccc2c1
Structure:
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